Download PDF High Throughput Screening: The Discovery of Bioactive Substances

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Click on the cover image above to read some pages of this book! Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening HTS systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.

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It will serve as a standard text in the field. It gives a very useful and clear description of the development of HTS systems from finding resources and generating libraries to assay and detection methods and finally automation, data handling and laboratory design. Help Centre. My Wishlist Sign In Join. Be the first to write a review. Add to Wishlist. Ships in 7 to 10 business days. Link Either by signing into your account or linking your membership details before your order is placed. Description Table of Contents Product Details Click on the cover image above to read some pages of this book!

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This website provides a unique collection of probes with their associated data, control compounds and recommendations on their use as well as a way to order the molecules. Boehringer Ingelheim Open Innovation Portal. Probe Miner suitable probes.

Laboratory Automation, High Throughput Screening and Drug Discovery

Probe Miner. Only compounds labeled as suitable probes were added to the set. Protein methyltransferases chemical toolbox. A chemical biology toolbox to study proteinmethyltransferases and epigenetic signaling. SGC Probes. Structural Genomics Consortium. Tool Compound Set.


Obsolete Compounds. Drug compound sets. Only compounds with available structure are uploaded ommiting compounds containing metal, and peptides. DrugBank ver.

High-throughput screening for bioactive components from traditional Chinese medicine.

Limited information on discontinued and drugs approved outside US is also available however regulatory approval information can't be verified. Other non-commercial compound sets. Bioprocess diversity set.

Functional annotation of chemical libraries across diverse biological processes. Clinical kinase drugs. The target landscape of clinical kinase drugs. They provide an open-access resource of target summaries that could help researchers develop better drugs, understand how existing drugs work, and design more effective clinical trials. Concise Guide to Pharmacology ver. This version provides concise overviews of the key properties of nearly human drug targets with an emphasis on selective pharmacology where available. This set contains only small-molecular ligands with available structure i.

Drug Repurposing Hub. We introduce a best-in-class drug screening collection with more than 3, clinical drugs.

High Throughput Screening: The Discovery of Bioactive Substances

The Repurposing Hub information resource contains extensive curated annotations for each drug, including details about commercial sources of all compounds. We invite you to explore the Hub information resource as a first step towards discovering new therapeutic applications for existing drugs. The hope is to generate probe molecules for the majority of the kinome that is as yet untargeted. Guide to Pharmacology ver.

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Guide to Pharmacology. In future versions we plan to add resources for education and training in pharmacological principles and techniques along with research guidelines and overviews of key topics.

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Informer Set ver. Broad Institute. We quantitatively measured the sensitivity of deeply characterized cancer-cell lines to Informer Set compounds, and have undertaken analyses connecting sensitivity to cancer features, including mutations, gene expression, copy-number variation, and lineage. Hence, our objective is to provide comprehensive and cost-effect HTS services, making HTS accessible and useful to all investigators. To accelerate the finding from the curiosity driven study to medical practice has become the main subject that we are facing today.

Thanks to the advance in molecular biology and informatics, investigators can now reveal more clearly than before the potential disease targets and molecular pathways which they involve. On the other hand, the use of natural occurring and synthetic small molecules for the treatment of diseases is well established in human history. In addition, this Resource Center has medicinal chemists and cheminformatics talents to add values to HTS screening services.

It is one important platform at the initial stage of translation research for multi-disciplinary collaboration, linking chemists and biologists to explore disease targets and identify potential interesting compounds for both mechanism studies and drug discovery.